Tiana Huynh, MS

PhD Candidate
City of Hope - Irell and Manella Graduate School of Biological Sciences

I am a 5th year PhD Candidate in Dr. Alexey Danilov's lab located at City of Hope in Los Angeles, California. My project focuses on understanding the effects of BTK degraders (i.e., zelebrudomide and bexobrutideg - developed by Nurix Therapeutics, Inc.) on the immune microenvironment in the context of chronic lymphocytic leukemia.

Poster(s):

• 1309 - Effects of Pirtobrutinib, a non-covalent BTK inhibitor, on T-cell function in chronic lymphocytic leukemia (CLL)

• 1312 - Zelebrudomide (NX-2127) is a cereblon-modulating BTK degrader that reverses immune dysfunction and modifies both T-cell and CLL-cell transcriptional signatures in patients with CLL