Faculty of Medicine University of Coimbra (FMUC), Coimbra, Portugal, Laboratory of Oncobiology and Hematology (LOH) and University Clinics of Hematology and Oncology, Coimbra Institute for Clinical and Biomedical Research (iCBR/CIMAGO), Faculty of Medicine University of Coimbra (FMUC), Coimbra, Portugal; Center for Innovative Biomedicine and Biotecnology (CIBB), Coimbra, Portugal, Clinical Academic Centre of Coimbra (CACC), Portugal