Faculty of Medicine University of Coimbra (FMUC); Laboratory of Oncobiology and Hematology (LOH) and University Clinics of Hematology and Oncology, Coimbra Institute for Clinical and Biomedical Research (iCBR/CIMAGO), Faculty of Medicine University of Coimbra (FMUC); Center for Innovative Biomedicine and Biotecnology (CIBB); Clinical Academic Centre of Coimbra (CACC), Portugal