YIM

YIM Session 2: Translational Research with Novel Agents and the Impact of the Microenvironment

Friday, September 12, 2025

09:35 - 10:45 CEST

Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1

Co-Chair(s)

Marek Mraz, MD, PhD

PI
CEITEC Masaryk University and University Hospital Brno
Brno, Czech Republic
Alan Ramsay, PhD

Reader (Associate Professor) in Lymphoma Biology
Lymphoma Immunology Group, Kings College London
London, England, United Kingdom

Presentations:

09:35 - 09:45 CEST

IFNγ/IL21-JAK-STAT1 Signaling Axis Drives T-Cell–Mediated CLL Proliferation and Venetoclax Resistance
Primary Author / Presenter: Miroslav Boudny, PhD – Dept of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Rep.; CEITEC, Masaryk University
09:45 - 09:55 CEST

SF3B1 K700E Mutation Promotes SAT1-Mediated Metabolic Reprogramming and Suppresses T-cell Immune Response in Chronic Lymphocytic Leukemia
Primary Author / Presenter: Hao Guo, MD, PhD – Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
09:55 - 10:05 CEST

Targeting BTKi-Resistant CLL Using the Dual Irreversible/Reversible 4th Generation BTK Inhibitor Rocbrutinib
Primary Author / Presenter: Britten K. Gordon, BS – The Ohio State University
10:05 - 10:10 CEST

Targeting Lysosomes in the Chronic Lymphocytic Leukemia Microenvironment
Primary Author / Presenter: Madhumita Manivannan – University of Alberta
10:10 - 10:15 CEST

EGR2 Hotspot Mutations Drive BTKi Resistance in Chronic Lymphocytic Leukemia via CD27-CD70 Interaction-Mediated T-Cell Exhaustion
Primary Author: Huayuan Zhu, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
Co-Author / Presenter: Dan Yang, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
10:15 - 10:20 CEST

Imaging mass cytometry reveals distinct cellular architectures in proliferative and non-proliferative regions of the chronic lymphocytic leukaemia lymph node tumour microenvironment
Primary Author / Presenter: Paul R. Buckley, PhD – King's College London
10:20 - 10:25 CEST

Subversion of ERK-MAPK-mediated mRNA translation elongation as a therapeutic strategy in CLL
Primary Author / Presenter: Jodie F. Hay, PhD – University of Glasgow
10:25 - 10:30 CEST

Investigating the eEF2K/eEF2 axis as a potential target in CLL following nelfinavir treatment
Primary Author / Presenter: Jiatian Li, PhD student – University of Glasgow
10:30 - 10:45 CEST

Panel Discussion