YIM Session 1: Pathogenesis of CLL

Co-Chair(s)

• 

  Elisa ten Hacken, PhD

  Assistant Professor
  Weill Cornell Medicine
  New York, New York, United States
• EG

  Emanuela Ghia, PhD

  Scientific Director of Biobanking and Correlative Sciences; Project Scientist
  Center for Novel Therapeutics; University of California, San Diego
  La Jolla, California, United States

Presentations:

• 08:10 - 08:20 CEST

  Targeting SF3B1 Disrupts Chronic Lymphocytic Leukemia Survival via PFKFB-mediated Glycolytic Dependency
  

  Primary Author: Yongyi Yuan, MS – Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital

  Co-Author / Presenter: Hao Guo, MD, PhD – Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
• 08:20 - 08:30 CEST

  Integrating phosphoproteomic analysis and innovative 3D cell culture systems to dissect the role of extracellular stiffness in CLL pathogenesis
  

  Primary Author / Presenter: Marco Cellani, MSc – Division of Experimental Oncology, Malignant B cells biology and 3D modelling Unit, San Raffaele Hospital (IRCCS)
• 08:30 - 08:40 CEST

  Long Non-Coding RNA LINC00173 Regulates BCR Signaling Propensity and mRNA Translation via Ribonucleoprotein Granules in CLL Cells
  

  Primary Author / Presenter: Pedro Faria Zeni, MSc – Dept of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Rep.; CEITEC, Masaryk University
• 08:40 - 08:45 CEST

  Unraveling the NOTCH1/MSI2/c-MYC Signaling Pathway Reveals a Novel Vulnerability in Chronic Lymphocytic Leukemia Progression
  

  Primary Author / Presenter: Juliana Querol Rivas, PhD student – Research Laboratory on Chronic Lymphocytic Leukemia, Institut Pasteur, Uruguay
• 08:45 - 08:50 CEST

  Immunological Landscape of CLL Development and Response to Early BTK Inhibition in del(13q14) Mice
  

  Primary Author / Presenter: Patricia Fernández-Guzmán, PhD student – Vall d'Hebron Institute of Oncology (VHIO)
• 08:50 - 08:55 CEST

  KRAS^G13D-Dependent PI3K/AKT Signaling Regulates Fatty Acid Oxidation in Chronic Lymphocytic Leukemia
  

  Primary Author: Ya ZHANG, MD – Shandong Provincial Hospital Affiliated to Shandong First Medical University

  Co-Author / Presenter: Jun Ma – Shandong Provincial Hospital Affiliated to Shandong First Medical University
• 08:55 - 09:00 CEST

  Normal B Cells in MBL Show Abnormal Transcriptomic and Subset Distributions Compared to Healthy Donors: Evidence for Follicular Maturation in IGHV-Mutated MBL and Extrafollicular Maturation in IGHV-Unmutated MBL
  

  Primary Author / Presenter: Gonzalo Blanco, PhD – The Feinstein Institutes for Medical Research
• 09:00 - 09:15 CEST

  Panel Discussion