Speaker: Tadeusz Robak, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Chair: Bartosz Pula, MD, PhD – Department of Hematology, Medical University of Lodz;
Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
08:00 - 08:10 CEST
YIM Welcome and Introductions
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Speaker: Tadeusz Robak, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Chair: Bartosz Pula, MD, PhD – Department of Hematology, Medical University of Lodz;
Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author: Yongyi Yuan, MS – Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
Co-Author / Presenter: Hao Guo, MD, PhD – Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
08:20 - 08:30 CEST
(1016) Integrating Phosphoproteomic Analysis and Innovative 3D Cell Culture Systems to Dissect the Role of Extracellular Stiffness in CLL Pathogenesis
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Marco Cellani, MSc – Division of Experimental Oncology, Malignant B cells biology and 3D modelling Unit, San Raffaele Hospital (IRCCS)
08:30 - 08:40 CEST
(1017) Long Non-Coding RNA LINC00173 Regulates BCR Signaling Propensity and mRNA Translation via Ribonucleoprotein Granules in CLL Cells
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Pedro Faria Zeni, MSc – Dept of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Rep.; CEITEC, Masaryk University
08:40 - 08:45 CEST
(1018) Unraveling the NOTCH1/MSI2/c-MYC Signaling Pathway Reveals a Novel Vulnerability in Chronic Lymphocytic Leukemia Progression
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Juliana Querol Rivas, PhD student – Research Laboratory on Chronic Lymphocytic Leukemia, Institut Pasteur, Uruguay
08:45 - 08:50 CEST
(1019) Immunological Landscape of CLL Development and Response to Early BTK Inhibition in del(13q14) Mice
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author: Ya ZHANG, MD – Shandong Provincial Hospital Affiliated to Shandong First Medical University
Co-Author / Presenter: Jun Ma – Shandong Provincial Hospital Affiliated to Shandong First Medical University
08:55 - 09:00 CEST
(1021) Normal B Cells in MBL Show Abnormal Transcriptomic and Subset Distributions Compared to Healthy Donors: Evidence for Follicular Maturation in IGHV-Mutated MBL and Extrafollicular Maturation in IGHV-Unmutated MBL
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Gonzalo Blanco, PhD – The Feinstein Institutes for Medical Research
09:00 - 09:15 CEST
Panel Discussion
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
YIM
09:15 - 09:35 CEST
Morning Break
09:15 - 09:35 CEST
Morning Break
Location: ICE, Foyer 0, Level 0
09:35 - 10:45 CEST
YIM Session 2: Translational Research with Novel Agents and the Impact of the Microenvironment
Co-Chair: Marek Mraz, MD, PhD – CEITEC Masaryk University and University Hospital Brno
Co-Chair: Alan G. Ramsay, PhD – Lymphoma Immunology Group, Kings College London
YIM
09:35 - 10:45 CEST
YIM Session 2: Translational Research with Novel Agents and the Impact of the Microenvironment
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Co-Chair: Marek Mraz, MD, PhD – CEITEC Masaryk University and University Hospital Brno
Co-Chair: Alan G. Ramsay, PhD – Lymphoma Immunology Group, Kings College London
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Miroslav Boudny, PhD – Dept of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Rep.; CEITEC, Masaryk University
09:45 - 09:55 CEST
(1203) SF3B1 K700E Mutation Promotes SAT1-Mediated Metabolic Reprogramming and Suppresses T-Cell Immune Response in Chronic Lymphocytic Leukemia
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Hao Guo, MD, PhD – Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
09:55 - 10:05 CEST
(1801) Targeting BTKi-Resistant CLL Using the Dual Irreversible/Reversible 4th Generation BTK Inhibitor Rocbrutinib
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
(1204) EGR2 Hotspot Mutations Drive BTKi Resistance in Chronic Lymphocytic Leukemia via CD27-CD70 Interaction-Mediated T-Cell Exhaustion
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author: Huayuan Zhu, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
Co-Author / Presenter: Dan Yang, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
10:15 - 10:20 CEST
(1210) Imaging Mass Cytometry Reveals Distinct Cellular Architectures in Proliferative and Non-Proliferative Regions of the Chronic Lymphocytic Leukaemia Lymph Node Tumour Microenvironment
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
YIM
10:45 - 11:05 CEST
Morning Break #2
10:45 - 11:05 CEST
Morning Break #2
Location: ICE, Foyer 0, Level 0
11:05 - 12:00 CEST
YIM Session 3: Richter Transformation
Co-Chair: Philip Thompson, MB, BS (Hons) – Peter MacCallum Cancer Centre & Royal Melbourne Hospital; The Sir Peter MaCallum Department of Clinical Oncology, University of Melbourne
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Co-Chair: Philip Thompson, MB, BS (Hons) – Peter MacCallum Cancer Centre & Royal Melbourne Hospital; The Sir Peter MaCallum Department of Clinical Oncology, University of Melbourne
(1022) Unravelling the Clinical and Biological Features of Accelerated Chronic Lymphocytic Leukemia
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Francesco Angotzi, MD – Hematology Unit, University of Padova
11:15 - 11:25 CEST
(1602) Venetoclax in Combination With Chemotherapy in Richter Syndrome Patients: A Real-life Experience
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Laura Ballotta, MD – Hematology Unit, ASUGI Azienda Universitaria Giuliano Isontina, Maggiore Hospital
11:25 - 11:35 CEST
(1601) Central Nervous System Involvement in Patients With Richter Transformation
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Domitilla Baccon – Department of Hematology, Mayo Clinic
11:35 - 11:45 CEST
(1603) Single-Cell Transcriptome Analysis Reveals Molecular Mechanism of Stem-Like Cells in Richter Transformation
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Ziyuan Zhou, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
11:45 - 12:00 CEST
Panel Discussion
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
YIM
12:00 - 12:45 CEST
Lunch
12:00 - 12:45 CEST
Lunch
Location: ICE, Foyer 0, Level 0
12:45 - 13:50 CEST
YIM Session 4: Clinical Approach Considerations and Treatment Options in CLL
Co-Chair: Moritz Fürstenau, MD – Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne and Duesseldorf, German CLL Study Group, Faculty of Medicine and University Hospital Cologne, University of Cologne
Co-Chair: Elżbieta Iskierka-Jażdżewska, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital in Lodz, Poland
YIM
12:45 - 13:50 CEST
YIM Session 4: Clinical Approach Considerations and Treatment Options in CLL
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Co-Chair: Moritz Fürstenau, MD – Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne and Duesseldorf, German CLL Study Group, Faculty of Medicine and University Hospital Cologne, University of Cologne
Co-Chair: Elżbieta Iskierka-Jażdżewska, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital in Lodz, Poland
YIM
12:45 - 12:55 CEST
(1209) Early Effects of Venetoclax Monotherapy on Immune Cells in Patients With Chronic Lymphocytic Leukemia
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Olina Lind, MSc – Department of Oncology-Pathology, Karolinska Institutet
12:55 - 13:05 CEST
(1503) Analysis of Resistance-Related Mutations in Patients With Chronic Lymphocytic Leukemia Treated With BTK or BCL2 Inhibitors Suggests Different Underlying Resistance Mechanisms and Subclonal Dynamics
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Miguel Bastos-Boente, PhD candidate – Servicio de Hematología, Hospital Universitario de Salamanca (HUS – IBSAL), CIBERONC y Centro de Investigación del Cáncer de Salamanca – IBMCC (CIC – USAL)
13:05 - 13:10 CEST
(1119) MYD88 Mutations in Chronic Lymphocytic Leukemia Exhibit Distinct Biological Behaviors and Prognostic Implications
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Yuting Yan, PhD – Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
13:10 - 13:15 CEST
(1701) Development and Evaluation of a Selection-Algorithm Optimised Ensemble Model for Predicting Infection Risk in CLL Using Structured and Unstructured Electronic Patient Record Data
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
(1439) Ten-Year Follow-Up of a Phase II Study of Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Aseel Alsouqi, MD – The Ohio State University
13:20 - 13:25 CEST
(1120) Serum LC-MS Based Untargeted Metabolomics Machine Learning for Distinguishing Asymptomatic and Symptomatic CLL/SLL and Predicting TTFT
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author: Huayuan Zhu, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
Co-Author / Presenter: Luomengjia Dai, MD – Department of Hematology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University
13:25 - 13:30 CEST
(1501) Efficacy and Tolerability of Venetoclax Plus Rituximab in Relapsed or Refractory Chronic Lymphyocytic Leukemia-Real-World Analysis of Polish Adult Leukemia Study Group
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Primary Author / Presenter: Anita Soboń, MD – Department of Hematology, Institute of Hematology and Transfusion Medicine
13:30 - 13:35 CEST
(1102) Unravelling Prognostic Significance: Long-Read Nanopore Sequencing of TP53 and IGHV in Chronic Lymphocytic Leukaemia Patients in Tanzania
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
YIM
13:50 - 14:10 CEST
Afternoon Break
13:50 - 14:10 CEST
Afternoon Break
Location: ICE, Foyer 0, Level 0
14:10 - 14:55 CEST
YIM Keynote, YIM Awards, and Concluding Remarks
Co-Chair: Bartosz Pula, MD, PhD – Department of Hematology, Medical University of Lodz;
Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Co-Chair: Marek Mraz, MD, PhD – CEITEC Masaryk University and University Hospital Brno
YIM
14:10 - 14:55 CEST
YIM Keynote, YIM Awards, and Concluding Remarks
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Co-Chair: Bartosz Pula, MD, PhD – Department of Hematology, Medical University of Lodz;
Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Co-Chair: Marek Mraz, MD, PhD – CEITEC Masaryk University and University Hospital Brno
YIM
14:10 - 14:40 CEST
YIM Keynote Presentation
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
Keynote Speaker: Nicholas Chiorazzi, MD – The Feinstein Institutes for Medical Research, Northwell Health System
YIM
14:40 - 14:55 CEST
YIM Awards and Concluding Remarks
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
YIM
18:30 - 21:00 CEST
iwCLL Welcome Reception
18:30 - 21:00 CEST
iwCLL Welcome Reception
Location: Wawel Royal Castle
Saturday, September 13, 2025
07:15 - 08:15 CEST
Coffee & Tea
07:15 - 08:15 CEST
Coffee & Tea
Location: ICE, Foyer 0, Level 0
08:15 - 08:25 CEST
Welcome and Introductions
Chair: Tadeusz Robak, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Speaker: Iwona Hus, MD, PhD – National Medical Institute of the Ministry of the Interior and Administration
08:15 - 08:25 CEST
Welcome and Introductions
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Chair: Tadeusz Robak, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital
Speaker: Iwona Hus, MD, PhD – National Medical Institute of the Ministry of the Interior and Administration
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Frederik Damm, MD – Dept of Hematology, Oncology, & Cancer Immunology, Charité - Universitätsmedizin Berlin
09:25 - 09:40 CEST
Panel Discussion with Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
09:40 - 09:50 CEST
(1022) Unravelling the Clinical and Biological Features of Accelerated Chronic Lymphocytic Leukemia
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Francesco Angotzi, MD – Hematology Unit, University of Padova
09:50 - 10:00 CEST
(1024) ROR1-Signaling Enhances Survival and Drug-Resistance of del(17p)/TP53-Mutated CLL by Mitigating Oxidative Stress Via Activation of NRF2
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Emanuela M. Ghia, PhD – Center for Novel Therapeutics; University of California, San Diego
Oral
10:00 - 10:10 CEST
(1023) Clinical and Biological Impact of MYC Overexpression in Chronic Lymphocytic Leukemia With and Without TP53 Disruption
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Alba Garrote de Barros, MSc – Department of Translational Hematology, Instituto de Investigación Hospital 12 de Octubre (imas12), Hematological Malignancies Clinical Research Unit H12O-CNIO, CIBERONC, ES 28041
10:10 - 10:15 CEST
(1001) IgM Monoclonal Gammopathy Arises Directly From MBL/CLL Cells: Evidence From Proteomic Analyses
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author: Uday Aditya Sarkar, PhD – Dana-Farber Cancer Institute, Harvard Medical School
Co-Author / Presenter: Paolo Ghia, MD, PhD – Università Vita Salute and IRCCS Ospedale San Raffaele
10:15 - 10:35 CEST
Morning Break
10:15 - 10:35 CEST
Morning Break
Location: ICE, Foyer 1, Level 1
10:35 - 12:20 CEST
Session 2: Genomics, Epigenetics, and Proteomics of CLL
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Ferran Nadeu, PhD – Institut d'Investigacions Biomèdiques August Pi i Sunyer
10:50 - 11:05 CEST
Epigenetics
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Inaki Martin-Subero, PhD – Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
11:05 - 11:20 CEST
Proteomics
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Fabienne Meier-Abt, MD, PhD – Institute of Medical Genetics, University of Zurich; Department of Medical Oncology and Hematology, University Hospital Zurich
11:20 - 11:35 CEST
Proteomics Changes During Ibrutinib Therapy
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Panel Discussion with Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
11:50 - 12:00 CEST
(1121) High-Risk Molecular Features Eclipse Genomic Complexity in Predicting CLL Patient Outcomes; Insights From the UK CLL4, ARCTIC, and ADMIRE Trials
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Helen Parker, PhD – University of Southampton
12:00 - 12:10 CEST
(1122) Integrative Epi(genome) Analysis of CD49d Bbimodal Expression Reveals Epigenetically Driven Phenotypic Transitions in CLL
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Federico Pozzo, PhD – Centro di Riferimento Oncologico di Aviano
12:10 - 12:15 CEST
(1102) Unravelling Prognostic Significance: Long-Read Nanopore Sequencing of TP53 and IGHV in Chronic Lymphocytic Leukaemia Patients in Tanzania
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Beyond Adhesion: Integrin Crosstalk With the BCR in CLL
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Tanja Nicole Hartmann, Prof., Dr. – Medical Center University Freiburg, Head Research and Clinical Research Coordination, Comprehensive Cancer Center Freiburg
14:15 - 14:35 CEST
Understanding the Role and Targeting the Non-Lymphoid Elements in the Tumor Microenvironment
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Alan G. Ramsay, PhD – Lymphoma Immunology Group, Kings College London
14:35 - 14:55 CEST
Extracellular Vesicles in CLL
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Miroslav Boudny, PhD – Dept of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Rep.; CEITEC, Masaryk University
15:15 - 15:20 CEST
(1209) Early Effects of Venetoclax Monotherapy on Immune Cells in Patients With Chronic Lymphocytic Leukemia
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Olina Lind, MSc – Department of Oncology-Pathology, Karolinska Institutet
15:20 - 15:40 CEST
Afternoon Break
15:20 - 15:40 CEST
Afternoon Break
Location: ICE, Foyer 1, Level 1
15:40 - 17:10 CEST
Session 4: Preclinical Studies of Novel Therapies
Co-Chair: Paolo Ghia, MD, PhD – Università Vita Salute and IRCCS Ospedale San Raffaele
Co-Chair: Shih-Shih Chen, PhD – The Feinstein Institutes for Medical Research
15:40 - 17:10 CEST
Session 4: Preclinical Studies of Novel Therapies
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Co-Chair: Paolo Ghia, MD, PhD – Università Vita Salute and IRCCS Ospedale San Raffaele
Co-Chair: Shih-Shih Chen, PhD – The Feinstein Institutes for Medical Research
15:40 - 15:55 CEST
Exploring Siglec-6 as a Novel Target for Potential Therapeutic Utility in Chronic Lymphocytic Leukemia
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Lessons From Solid Tumors for CLL: Harnessing B Cells Inside and Outside of Tertiary Lymphoid Structures for New Therapeutics
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Tullia Bruno, PhD – The University of Pittsburgh Hillman Cancer Center
16:25 - 16:35 CEST
(1311) Targeted Degradation of NF-κB RelA/p65 by PBD-Based PROTACs as a Novel Therapeutic Strategy in Chronic Lymphocytic Leukaemia
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Chris Pepper, PhD – Brighton and Sussex Medical School
16:35 - 16:45 CEST
(1312) Zelebrudomide (NX-2127) Is a Cereblon-Modulating BTK Degrader That Reverses Immune Dysfunction and Modifies Both T-cell and CLL-Cell Transcriptional Signatures in Patients With CLL
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Tiana Huynh, MS – City of Hope - Irell and Manella Graduate School of Biological Sciences
16:45 - 16:50 CEST
(1305) CLECL1⁺ Proliferative CLL Cells Remodel the Lymph Node Microenvironment Through Fibroblast Reprogramming, Th2 Polarization, and M2 Macrophage Induction to Promote Immune Evasion and Disease Progression
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Shih-Shih Chen, PhD – The Feinstein Institutes for Medical Research
16:50 - 16:55 CEST
(1303) Targeting Lysosomes in the Chronic Lymphocytic Leukemia Microenvironment
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Goals of Treatment Aligning With Continuum of Disease and Impact of First-Line Choices
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Jennifer A. Woyach, MD – Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center
08:35 - 08:55 CEST
Individualizing First-Line Treatment Choice Based on Patient and Disease Characteristics
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Nitin Jain, MD – The University of Texas MD Anderson Cancer Center
08:55 - 09:10 CEST
Panel Discussion With Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
09:10 - 09:20 CEST
(1442) NGS-Based MRD Assessment Refines Prognostication After Venetoclax-Based First-Line Combinations for Chronic Lymphocytic Leukemia: A Prospective Analysis of the Phase 3 GAIA/CLL13 Trial
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Moritz Fürstenau, MD – Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne and Duesseldorf, German CLL Study Group, Faculty of Medicine and University Hospital Cologne, University of Cologne
09:20 - 09:25 CEST
(1438) Central Nervous System Involvement in Chronic Lymphocytic Leukemia: An International Retrospective Study by ERIC, the European Research Initiative on CLL
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Thomas Chatzikonstantinou, MD – Institute of Applied Biosciences, Centre for Research and Technology Hellas
09:25 - 10:40 CEST
Session 6: How I Treat Double Relapsed/Refractory CLL
How Do I Treat Double Refractory Patients With Cellular Therapy?
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Philip Thompson, MB, BS (Hons) – Peter MacCallum Cancer Centre & Royal Melbourne Hospital; The Sir Peter MaCallum Department of Clinical Oncology, University of Melbourne
10:10 - 10:25 CEST
Panel Discussion With Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
10:25 - 10:30 CEST
(1440) Transcriptional Reprogramming and Survival Co-Dependencies of Chronic Lymphocytic Leukemia Resistant to Venetoclax
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Deepa Sampath, PhD – University of Texas MD Anderson Cancer Center
10:30 - 10:35 CEST
(1441) A functional prognostic model predicts progression free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Current and Future Management of Richter Transformation
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Othman Al-Sawaf, MD PhD – Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital
12:35 - 12:45 CEST
Panel Discussion With Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
12:45 - 12:55 CEST
(1607) MGA Loss drives cristae remodeling and redox adaptation via MICOS and PRDX2 in Richters transformation
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Prajish S. Iyer, PhD – Department of Systems Biology, Beckman Research Institute, City of Hope
12:55 - 13:05 CEST
(1606) Epcoritamab Monotherapy in Patients with First-Line Richter’s Transformation: 2-Year Follow-Up Results From the Phase 1b/2 EPCORE CLL-1 Clinical Trial
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Arnon P. Kater, MD, PhD – Department of Hematology, Amsterdam UMC, Cancer Center Amsterdam, University of Amsterdam, and HOVON
13:05 - 13:55 CEST
Lunch
13:05 - 13:55 CEST
Lunch
Location: ICE, Foyer 0, Level 0
13:55 - 14:55 CEST
Industry Supported Symposium Platinum Sponsor
13:55 - 14:55 CEST
Industry Supported Symposium
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
13:55 - 14:55 CEST
Industry Supported Symposium: Innovative Approaches in CLL: Tailoring Treatment to Transform Patient Outcomes
13:55 - 14:55 CEST
Industry Supported Symposium: Innovative Approaches in CLL: Tailoring Treatment to Transform Patient Outcomes
Location: ICE, Theater Hall (S2), Entrances On Level 0 & 1
15:00 - 15:45 CEST
Session 8: Health Maintenance for Patients With CLL
Panel Discussion With Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
15:40 - 15:45 CEST
(1717) MVA-Based GEO-CM04S1 Vaccine Results in Improved Cellular Immune Response in Patients With Chronic Lymphocytic Leukemia (CLL) Compared With mRNA-Based Vaccine: Initial Results of a Phase II Randomized Study
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Alexey V. Danilov, MD, PhD – Department of Hematology and Transplantation, City of Hope National Medical Center
15:45 - 15:55 CEST
Binet/Rai Medal Presentation
15:45 - 15:55 CEST
Binet/Rai Medal Presentation
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: J. Joseph Melenhorst, PhD – Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic
10:45 - 11:00 CEST
CAR Therapies: Beyond T-cells and CD19 as the Target
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Sunil Acharya, PhD – The University of Texas MD Anderson Cancer Center
11:00 - 11:15 CEST
Panel Discussion With Interactivity and Audience Q&A
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
11:15 - 11:25 CEST
(1912) A Tandem CD19/ROR1 CAR-NK to Overcome Apoptotic Resistance in Chronic Lymphocytic Leukemia
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Andrew Lu, SB – Dana Farber Cancer Institute
11:25 - 11:30 CEST
(1902) Impact of Treatment With Ibrutinib or Venetoclax on CAR-T Cell Generation in Patients With Chronic Lymphocytic Leukemia. Interim Analysis of the GIMEMA CLL2020 Study
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Primary Author / Presenter: Marta Coscia, MD, PhD – Department of Medicine and Surgery, University of Insubria and Department of Oncology, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi
11:30 - 12:20 CEST
Lunch
11:30 - 12:20 CEST
Lunch
Location: ICE, Foyer 0, Level 0
12:20 - 12:50 CEST
Keynote Presentation: Measurable Residual Disease in Chronic Lymphocytic Leukemia: Technical Aspects and Clinical Significance
Location: ICE, Auditorium Hall (S1), Entrances On Level 0 & 1
Speaker: Tadeusz Robak, MD, PhD – Department of Hematology, Medical University of Lodz; Department of General Hematology and Internal Medicine, Copernicus Memorial Hospital